THE POWER OF GEOHISTORICAL BOUNDARIES FOR MODELING THE GENETIC BACKGROUND OF HUMAN POPULATIONS: THE CASE OF THE RURAL CATALAN PYRENEES

The power of geohistorical boundaries for modeling the genetic background of human populations: The case of the rural catalan Pyrenees

The genetic variation of the European population at a macro-geographic scale follows genetic gradients which reflect main migration events.However, less is known about factors affecting mating patterns at a micro-geographic scale.In this study we have analyzed 726,718 autosomal single nucleotide variants in 435 individuals from the Electronic Switc

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Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis

Glucocorticoids are widely used as an ophthalmic medication.A common, sight-threatening adverse event of glucocorticoid usage is ocular hypertension, caused by dysfunction of the conventional outflow pathway.We report that netarsudil, a rho-kinase inhibitor, BMX Spokes decreased glucocorticoid-induced ocular hypertension in patients whose intraocul

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